OPHEP LOGBOOK IHR ART. 6 · 24H NOTIFICATION IHR ART. 10 · 24H VERIFICATION ANNEX 2 · 48H ASSESSMENT GATE INDEPENDENT HISTORICAL LOGBOOK
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Outbreak and Public Health Event Portal IHR (2005) Annex 2 Bilingual Signal Logbook
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Pathogen Classification Matrix · IHR Annex 2

High-Threat Pathogen Watchlist & Annex 2 Notification Matrix

Filter Box A mandatory-notification diseases, Box B priority agents, and vector-borne regional threats alongside specimen triage protocols.

Epidemiological line-list and outbreak logbook for high-threat pathogen monitoring
Pathogen triage register mapping clinical syndromes to Box A and Box B statutory pathways.
Classification Rule

IHR (2005) Annex 2 places four diseases—smallpox, wild-type poliomyelitis, human influenza caused by a new subtype, and SARS—into Box A for unconditional 24-hour notification, while cholera, pneumonic plague, yellow fever, viral haemorrhagic fevers, West Nile fever, and regional priority agents in Box B require scoring all four Annex 2 risk criteria.

Statutory reference: WHO IHR (2005) Annex 2 Decision Instrument.

Filterable Pathogen Notification Directory

Pathogen / Disease Annex 2 Tier Clinical Signal Trigger Diagnostic Assay Notification Rule
Smallpox (Variola virus) Box A Single suspected vesicular-pustular case PCR / Reference lab confirmation Always notify within 24h (Art. 6)
Poliomyelitis (Wild-type poliovirus) Box A Acute flaccid paralysis (AFP) <15y Two stool cultures (24–48h apart) Always notify within 24h (Art. 6)
Human Influenza (New Subtype) Box A Severe SARI with novel haemagglutinin RT-PCR subtyping / sequencing Always notify within 24h (Art. 6)
SARS (SARS-CoV) Box A Unexplained atypical pneumonia cluster RT-PCR / paired serology Always notify within 24h (Art. 6)
Cholera (Vibrio cholerae) Box B Acute watery diarrhoea surge / severe dehydration RDT + stool culture / PCR Notify 24h if ≥2 criteria met
Pneumonic Plague (Yersinia pestis) Box B Rapidly fatal haemoptysis & respiratory distress Sputum smear / PCR / culture Notify 24h if ≥2 criteria met
Yellow Fever Box B Acute fever with jaundice & bleeding IgM ELISA / RT-PCR Notify 24h if ≥2 criteria met
Viral Haemorrhagic Fevers (Ebola, Marburg, Lassa, CCHF) Box B Febrile haemorrhage / healthcare cluster BSL-3/4 RT-PCR / antigen ELISA Notify 24h if ≥2 criteria met
MERS-CoV (Regional Respiratory Priority) Box B / Regional SARI with camel or hospital exposure Lower respiratory RT-PCR Notify 24h if ≥2 criteria met
Rift Valley Fever / West Nile Fever Vector / Box B Human encephalitis or livestock abortion storm IgM capture ELISA / RT-PCR Notify 24h if ≥2 criteria met

Signal Escalation Overview

IHR (2005) Early Signal Verification and Notification Funnel STAGE 01 · T+0H Raw Signal Capture EWARN clinics, lab alerts, border desks & media triangulation intake Art. 5 Capacity STAGE 02 · <=24H Field Verification Rule out false rumors, confirm case definition & specimen transport Art. 10 Response STAGE 03 · <=48H Annex 2 Gate Screen Box A mandatory diseases or score 4 statutory risk criteria 48h Assessment STAGE 04 · <=24H WHO Notification NFP formal dispatch to WHO Contact Point & PHEOC mobilization Art. 6 Mandatory NFP assesses within 48h and notifies WHO within 24h once >= 2 Annex 2 criteria or Box A match.
Figure 1. Four-stage epidemic intelligence verification and IHR (2005) Article 6 / Article 10 statutory escalation funnel.
Historical Archive Anchor: /pathogens Watchlist Continuity

Legacy bookmarks to /pathogens land on this Annex 2 Box A / Box B directory, preserving deterministic diagnostic and reporting criteria.